Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0-Å Resolution-Reference-Cited by-同舟云学术

Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0-Å Resolution

Published:2010-01-08 Issue:4 Volume:77 Page:529-538
ISSN:0026-895X
Container-title:Molecular Pharmacology
language:en
Short-container-title:Mol Pharmacol

Author:

Gay Sean C.,Shah Manish B.,Talakad Jyothi C.,Maekawa Keiko,Roberts Arthur G.,Wilderman P. Ross,Sun Ling,Yang Jane Y.,Huelga Stephanie C.,Hong Wen-Xu,Zhang Qinghai,Stout C. David,Halpert James R.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference39 articles.

1. Investigation of the Mechanisms Underlying the Differential Effects of the K262R Mutation of P450 2B6 on Catalytic Activity

2. THE NATURALLY OCCURRING CYTOCHROME P450 (P450) 2B6 K262R MUTANT OF P450 2B6 EXHIBITS ALTERATIONS IN SUBSTRATE METABOLISM AND INACTIVATION

3. Activation of the Anticancer Prodrugs Cyclophosphamide and Ifosfamide: Identification of Cytochrome P450 2B Enzymes and Site-Specific Mutants with Improved Enzyme Kinetics

4. The CCP4 suite: programs for protein crystallography

5. Engineering Microsomal Cytochrome P450 2C5 to Be a Soluble, Monomeric Enzyme

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