A Mouse Model with Liver-Specific Deletion and Global Suppression of the NADPH-Cytochrome P450 Reductase Gene: Characterization and Utility for in Vivo Studies of Cyclophosphamide Disposition-Reference-Cited by-同舟云学术

A Mouse Model with Liver-Specific Deletion and Global Suppression of the NADPH-Cytochrome P450 Reductase Gene: Characterization and Utility for in Vivo Studies of Cyclophosphamide Disposition

Published:2007-01-11 Issue:1 Volume:321 Page:9-17
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Gu Jun,Chen Chong-Sheng,Wei Yuan,Fang Cheng,Xie Fang,Kannan Kurunthachalam,Yang Weizhu,Waxman David J.,Ding Xinxin

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference30 articles.

1. ENANTIOSELECTIVE METABOLISM AND CYTOTOXICITY OFR-IFOSFAMIDE ANDS-IFOSFAMIDE BY TUMOR CELL-EXPRESSED CYTOCHROMES P450

2. Activation of the Anticancer Prodrugs Cyclophosphamide and Ifosfamide: Identification of Cytochrome P450 2B Enzymes and Site-Specific Mutants with Improved Enzyme Kinetics

3. Immunoblot analysis and immunohistochemical characterization of CYP2A expression in human olfactory mucosa

4. Some electrical and pharmacological properties of gap junctions between adult ventricular myocytes

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