The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants-Reference-Cited by-同舟云学术

The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants

Published:2015 Issue:3 Volume:4 Page:548-562
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Arlt Volker M.¹²³⁴⁵,Henderson Colin J.⁶⁷⁸⁹¹⁰,Wolf C. Roland⁶⁷⁸⁹¹⁰,Stiborová Marie¹¹¹²¹³¹⁴¹⁵,Phillips David H.¹²³⁴⁵

Affiliation:

1. Analytical and Environmental Sciences Division

2. MRC-PHE Centre for Environment and Health

3. King's College London

4. London SE1 9NH

5. UK

6. Division of Cancer Research

7. Medical Research Institute

8. Jacqui Wood Cancer Centre

9. University of Dundee

10. Dundee DD1 9SY

11. Department of Biochemistry

12. Faculty of Science

13. Charles University

14. 128 40 Prague 2

15. Czech Republic

Abstract

This review describes the applicability of the Hepatic Reductase Null (HRN) and Reductase Conditional Null (RCN) mouse models to study carcinogen metabolism.

Funder

Cancer Research UK

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/TX/C4TX00116H

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