Concentration-Dependent Modulation of Amyloid-β in Vivo and in Vitro Using the γ-Secretase Inhibitor, LY-450139-Reference-Cited by-同舟云学术

Concentration-Dependent Modulation of Amyloid-β in Vivo and in Vitro Using the γ-Secretase Inhibitor, LY-450139

Published:2006-08-18 Issue:2 Volume:319 Page:924-933
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Lanz Thomas A.,Karmilowicz Michael J.,Wood Kathleen M.,Pozdnyakov Nikolay,Du Ping,Piotrowski Mary A.,Brown Tracy M.,Nolan Charles E.,Richter Karl E. G.,Finley James E.,Fei Qing,Ebbinghaus Charles F.,Chen Yuhpyng L.,Spracklin Douglas K.,Tate Barbara,Geoghegan Kieran F.,Lau Lit-Fui,Auperin David D.,Schachter Joel B.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference28 articles.

1. Reductions in β-amyloid concentrations in vivo by the γ-secretase inhibitors BMS-289948 and BMS-299897

2. Dynamics of β-Amyloid Reductions in Brain, Cerebrospinal Fluid, and Plasma of β-Amyloid Precursor Protein Transgenic Mice Treated with a γ-Secretase Inhibitor

3. In Vivo Characterization of Aβ(40) Changes in Brain and Cerebrospinal Fluid Using the Novel γ-Secretase Inhibitor N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the Rat

4. P-glycoprotein deficiency at the blood-brain barrier increases amyloid- deposition in an Alzheimer disease mouse model

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