Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active Doses-Reference-Cited by-同舟云学术

Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active Doses

Published:2022-05-11 Issue:7 Volume:50 Page:898-908
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Yang Zheng,Rajendran Surendran,Spires Vanessa,Poirson Brian,Gururajan Murali,Lin Zheng,Arbanas Jaren,Krystek Stanley,Loy James,Cheng Yuan,Carl Stephen,Pace Samantha,Wang Yun,Mehl John,Xu Shihua,Vasudevan Krishna,Broz Miranda,Lehman-McKeeman Lois,Morin Paul,Graziano Robert F.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference38 articles.

1. The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity

2. IL-10 expression by CT26 colon carcinoma cells inhibits their malignant phenotype and induces a T cell-mediated tumor rejection in the context of a systemic Th2 response

3. Effects of PEGylation and Immune Complex Formation on the Pharmacokinetics and Biodistribution of Recombinant Interleukin 10 in Mice

4. Concept of pharmacologic target-mediated drug disposition in large-molecule and small-molecule compounds;An;J Clin Pharmacol,2020

5. Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice;Berman;J Immunol,1996

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