Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model-Reference-Cited by-同舟云学术

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Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model

Published:2021-10-25 Issue:1 Volume:50 Page:33-42
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Mennillo Elvira,Yang Xiaojing,Weber Andre A.,Maruo Yoshihiro,Verreault Melanie,Barbier Olivier,Chen Shujuan,Tukey Robert H.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference44 articles.

1. Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man;Bosma;J Biol Chem,1994

2. Role of p53 in irinotecan-induced intestinal cell death and mucosal damage

3. A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation

4. ERK Kinase Inhibition Stabilizes the Aryl Hydrocarbon Receptor

5. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11)

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Green tea extract prevents CPT-11-induced diarrhea by regulating the gut microbiota;Scientific Reports;2023-04-21

2. Oral arsenic administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR;Journal of Biological Chemistry;2023-03

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