Nonclinical Pharmacokinetics and Absorption, Distribution, Metabolism, and Excretion of Givosiran, the First Approved N-Acetylgalactosamine–Conjugated RNA Interference Therapeutic-Reference-Cited by-同舟云学术

Nonclinical Pharmacokinetics and Absorption, Distribution, Metabolism, and Excretion of Givosiran, the First Approved N-Acetylgalactosamine–Conjugated RNA Interference Therapeutic

Published:2021-05-03 Issue:7 Volume:49 Page:572-580
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Li Jing,Liu Ju,Zhang Xuemei,Clausen Valerie,Tran Chris,Arciprete Michael,Wang Qianfan,Rocca Carrie,Guan Li-Hua,Zhang Guodong,Najarian Diana,Xu Yuanxin,Smith Peter,Wu Jing-Tao,Chong Saeho

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference21 articles.

1. Pharmacokinetics and pharmacodynamics of the small interfering ribonucleic acid, givosiran, in patients with acute hepatic porphyria;Agarwal;Clin Pharmacol Ther,2020

2. The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs;Akinc;Nat Nanotechnol,2019

3. The porphyrias: advances in diagnosis and treatment

4. Phase 3 trial of RNAi therapeutic givosiran for acute intermittent porphyria;Balwani;N Engl J Med,2020

5. Acute Hepatic Porphyria

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Tracing the Evolution: A Comprehensive Bibliometric Analysis of Drug Interaction Clinical Studies;The Journal of Clinical Pharmacology;2024-08-14

2. Whole-Body Physiologically-Based Pharmacokinetic Modeling of GalNAc conjugated siRNAs;2024-08-06

3. Enhancing siRNA efficacy in vivo with extended nucleic acid backbones;Nature Biotechnology;2024-08-01

4. Metabolite profiling of chemically modified oligonucleotides in rat liver homogenates using hydrophilic interaction liquid chromatography-high resolution mass spectrometry;Microchemical Journal;2024-07

5. Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates;Nucleic Acids Research;2024-05-14