Novel Homodimer Metabolites of GDC-0994 via Cytochrome P450–Catalyzed Radical Coupling
Author:
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Subject
Pharmaceutical Science,Pharmacology
Reference40 articles.
1. Density‐functional thermochemistry. III. The role of exact exchange
2. Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis
3. Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor in early clinical development;Blake;J Med Chem,2016
4. Prevalence of Non-Cytochrome P450-Mediated Metabolism in Food and Drug Administration-Approved Oral and Intravenous Drugs: 2006-2015
5. Chemical Computing Group ULC (2018) Molecular Operating Environment (MOE), 2018.01, Chemical Computing Group ULC, Montreal, QC, Canada.
Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. The Importance of Tracking “Missing” Metabolites: How and Why?;Journal of Medicinal Chemistry;2023-09-28
2. Unusual Biotransformation Reactions of Drugs and Drug Candidates;Drug Metabolism and Disposition;2023-01-18
3. Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats;Xenobiotica;2022-03-04
4. Total synthesis of himastatin;Science;2022-02-25
5. Novel advances in biotransformation and bioactivation research – 2020 year in review;Drug Metabolism Reviews;2021-06-24
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3