Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development-Reference-Cited by-同舟云学术

Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development

Published:2016-06-07 Issue:12 Volume:59 Page:5650-5660
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Blake James F.¹,Burkard Michael¹,Chan Jocelyn²,Chen Huifen²,Chou Kang-Jye²,Diaz Dolores²,Dudley Danette A.²,Gaudino John J.¹,Gould Stephen E.²,Grina Jonas¹,Hunsaker Thomas²,Liu Lichuan²,Martinson Matthew¹,Moreno David¹,Mueller Lars²,Orr Christine²,Pacheco Patricia²,Qin Ann²,Rasor Kevin¹,Ren Li¹,Robarge Kirk²,Shahidi-Latham Sheerin²,Stults Jeffrey²,Sullivan Francis¹,Wang Weiru²,Yin Jianping²,Zhou Aihe²,Belvin Marcia²,Merchant Mark²,Moffat John²,Schwarz Jacob B.²

Affiliation:

1. Array BioPharma Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States

2. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00389

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