An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials-Reference-Cited by-同舟云学术

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An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Published:2019-03-25 Issue:6 Volume:47 Page:601-615
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Henderson C.J.,Kapelyukh Y.,Scheer N.,Rode A.,McLaren AW.,MacLeod A.K.,Lin D.,Wright J.,Stanley L.A.,Wolf C.R.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference62 articles.

1. P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity

2. Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine

3. Prediction of In Vivo Drug-Drug Interactions from In Vitro Data

4. Species differences in drug transporters and implications for translating preclinical findings to humans

5. Species differences in drug plasma protein binding

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