The Molecular Pharmacology and In Vivo Activity of 2-(4-Chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a Dual Inhibitor of Microsomal Prostaglandin E2 Synthase-1 and 5-Lipoxygenase-Reference-Cited by-同舟云学术

The Molecular Pharmacology and In Vivo Activity of 2-(4-Chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a Dual Inhibitor of Microsomal Prostaglandin E2 Synthase-1 and 5-Lipoxygenase

Published:2009-11-24 Issue:3 Volume:332 Page:840-848
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Koeberle Andreas,Rossi Antonietta,Zettl Heiko,Pergola Carlo,Dehm Friederike,Bauer Julia,Greiner Christine,Reckel Sina,Hoernig Christina,Northoff Hinnak,Bernhard Frank,Dötsch Volker,Sautebin Lidia,Schubert-Zsilavecz Manfred,Werz Oliver

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference39 articles.

1. Human Microsomal Prostaglandin E Synthase-1 (mPGES-1) Binding with Inhibitors and the Quantitative Structure−Activity Correlation

2. Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase

3. Activation of Peroxisome Proliferator-activated Receptor γ Inhibits Interleukin-1β-induced Membrane-associated Prostaglandin E2 Synthase-1 Expression in Human Synovial Fibroblasts by Interfering with Egr-1

4. Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

5. Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo

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