Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b5/NADH-b5Reductase in Variability of CYP3A Activity in Human Liver Microsomes-Reference-Cited by-同舟云学术

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Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b5/NADH-b5Reductase in Variability of CYP3A Activity in Human Liver Microsomes

Published:2008-10-06 Issue:1 Volume:37 Page:90-96
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Gan Lu,von Moltke Lisa L.,Trepanier Lauren A.,Harmatz Jerold S.,Greenblatt David J.,Court Michael H.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference35 articles.

1. Properties of NADH-cytochrome-b5 reductase from human neutrophils

2. The Influence of Age and Sex on the Clearance of Cytochrome P450 3A Substrates

3. Decrease in NADPH-Cytochrome P450 Reductase Activity of the Human Heart, Liver and Lungs in the Presence of Alpha-Lipoic Acid

4. Modification of the Nucleotide Cofactor-binding Site of Cytochrome P-450 Reductase to Enhance Turnover with NADH in Vivo

5. Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver

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