Cytochrome P450 2B6 Catalyzes the Formation of Pharmacologically Active Sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) Metabolites in Human Liver Microsomes-Reference-Cited by-同舟云学术

Cytochrome P450 2B6 Catalyzes the Formation of Pharmacologically Active Sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) Metabolites in Human Liver Microsomes

Published:2008-05-12 Issue:8 Volume:36 Page:1679-1688
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Bae Soo Kyung,Cao Shan,Seo Kyung-Ah,Kim Hyunmi,Kim Min-Jung,Shon Ji-Hong,Liu Kwang-Hyeon,Zhou Hong-Hao,Shin Jae-Gook

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference37 articles.

1. The Efficacy and Safety of Sibutramine for Weight Loss

2. Determination of the active metabolite of sibutramine by liquid chromatography–electrospray ionization tandem mass spectrometry

3. Thermogenic effects of sibutramine and its metabolites

4. Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro

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