Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin–Dependent Responses-Reference-Cited by-同舟云学术

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Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin–Dependent Responses

Published:2018-10-15 Issue:1 Volume:95 Page:1-10
ISSN:0026-895X
Container-title:Molecular Pharmacology
language:en
Short-container-title:Mol Pharmacol

Author:

Jagla Caitlin A. D.,Scott Caitlin E.,Tang Yaliang,Qiao Changjiang,Mateo-Semidey Gabriel E.,Yudowski Guillermo A.,Lu Dai,Kendall Debra A.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference46 articles.

1. Differential and competitive regulation of human melanocortin 1 receptor signaling by β-arrestin isoforms

2. Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and Gi Protein-independent ERK1/2 Kinase Activation

3. Profiling two indole-2-carboxamides for allosteric modulation of the CB1 receptor;Ahn;J Neurochem,2013

4. Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

5. CB1 Receptor Allosteric Modulators Display Both Agonist and Signaling Pathway Specificity

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2. G protein-coupled receptor (GPCR)-dependent transduction;Allosteric Modulation of G Protein-Coupled Receptors;2022

3. Pharmacological selection of cannabinoid receptor effectors: Signalling, allosteric modulation and bias;Neuropharmacology;2021-08

4. Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery;Trends in Pharmacological Sciences;2021-04

5. CB1 allosteric modulators and their therapeutic potential in CNS disorders;Progress in Neuro-Psychopharmacology and Biological Psychiatry;2021-03

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