Mutation of a Single Residue (K262R) in P450 2B6 Leads to Loss of Mechanism-Based Inactivation by Phencyclidine
Author:
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Subject
Pharmaceutical Science,Pharmacology
Reference30 articles.
1. Nonsubstrate Recognition Site Residues Are Involved in Testosterone Hydroxylation by Cytochrome P450 CYP 2C11
2. THE NATURALLY OCCURRING CYTOCHROME P450 (P450) 2B6 K262R MUTANT OF P450 2B6 EXHIBITS ALTERATIONS IN SUBSTRATE METABOLISM AND INACTIVATION
3. A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man
4. [22] The measurement of difference spectra: Application to the cytochromes of microsomes
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