Alanine-Scanning Mutagenesis of Transmembrane Domain 6 of the M1 Muscarinic Acetylcholine Receptor Suggests that Tyr381 Plays Key Roles in Receptor Function

Author:

Ward Stuart D. C.,Curtis Carol A. M.,Hulme Edward C.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference22 articles.

1. Functional role in ligand binding and receptor activation of an asparagine residue present in the sixth transmembrane domain of all muscarinic acetylcholine receptors.;Blüml;J Biol Chem,1994

2. Identification of a Family of Muscarinic Acetylcholine Receptor Genes

3. Analysis of cardiac muscarinic receptors recognized selectively by nonquaternary but not by quaternary ligands.;Brown;J Pharmacol Exp Ther,1986

4. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor.;De Lean;J Biol Chem,1980

5. A simple method for estimation of agonist activity at receptor subtypes: Comparison of native and cloned M3 muscarinic receptors in guinea pig ileum and transfected cells.;Ehlert;J Pharmacol Exp Ther,1999

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