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CYP2D6 Mediates 4-Hydroxylation of Clonidine In Vitro: Implication for Pregnancy-Induced Changes in Clonidine Clearance

  • Published:2010-06-22 Issue:9 Volume:38 Page:1393-1396
  • ISSN:0090-9556
  • Container-title:Drug Metabolism and Disposition
  • language:en
  • Short-container-title:Drug Metab Dispos

Author:

Claessens Adam J.,Risler Linda J.,Eyal Sara,Shen Danny D.,Easterling Thomas R.,Hebert Mary F.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference11 articles.

1. Pregnancy-Induced Changes in Pharmacokinetics

2. Clonidine Pharmacokinetics in Pregnancy

3. Pharmacokinetics and concentration-effect relationships of intravenous and oral clonidine;Davies;Clin Pharmacol Ther,1977

4. Dollery SC (1991) Clonidine (hydrochloride), in Therapeutic Drugs ( Dollery SC ed), pp C305–C311, Churchill Livingstone, New York.

5. Pregnancy-induced increase in metoprolol metabolism

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