The Utility of In Vitro Data in Making Accurate Predictions of Human P-Glycoprotein-Mediated Drug-Drug Interactions: A Case Study for AZD5672-Reference-Cited by-同舟云学术

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The Utility of In Vitro Data in Making Accurate Predictions of Human P-Glycoprotein-Mediated Drug-Drug Interactions: A Case Study for AZD5672

Published:2010-11-12 Issue:2 Volume:39 Page:275-282
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Elsby Robert,Gillen Michael,Butters Caroline,Imisson Gemma,Sharma Pradeep,Smith Veronica,Surry Dominic D.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference26 articles.

1. Digoxin-itraconazole interaction: possible mechanisms;Alderman;Ann Pharmacother,1997

2. P-gp Inhibition Potential in Cell-Based Models: Which “Calculation” Method is the Most Accurate?

3. Transport and epithelial secretion of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco-2) cells

4. Refining the In Vitro and In Vivo Critical Parameters for P-Glycoprotein, [I]/IC50 and [I2]/IC50, That Allow for the Exclusion of Drug Candidates from Clinical Digoxin Interaction Studies

5. Validation and application of Caco-2 assays for thein vitroevaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions

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