The Intestine As an Important Contributor to Prasugrel Active Metabolite Formation In Vivo-Reference-Cited by-同舟云学术

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The Intestine As an Important Contributor to Prasugrel Active Metabolite Formation In Vivo

Published:2010-12-28 Issue:4 Volume:39 Page:565-570
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Hagihara Katsunobu,Kazui Miho,Ikenaga Hidenori,Nanba Toshihiko,Fusegawa Kiichi,Izumi Takashi,Ikeda Toshihiko,Kurihara Atsushi

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference21 articles.

1. Formation of the isomers of the active metabolite of prasugrel by allelic variants of the human cytochrome P450 isozymes;Baker;Drug Metab Rev,2008

2. Population pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in aspirin-treated patients with stable coronary artery disease

3. Metabolism and Disposition of the Thienopyridine Antiplatelet Drugs Ticlopidine, Clopidogrel, and Prasugrel in Humans

4. Cytochrome P450 3A Inhibition by Ketoconazole Affects Prasugrel and Clopidogrel Pharmacokinetics and Pharmacodynamics Differently

5. The Disposition of Prasugrel, a Novel Thienopyridine, in Humans

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1. Pharmacokinetic/Pharmacodynamic Assessment of the Structural Refinement of Clopidogrel Focusing on the Balance between Bioactivation and Deactivation;Drug Metabolism and Disposition;2024-05-10

2. Evaluation of the changes in exposure to thiol compounds in chronic kidney disease patients using the PBPK model;Xenobiotica;2020-08-12

3. CYP2C19 and CYP3A4 activity and ADP-induced platelet reactivity in prasugrel- or ticagrelor-treated STEMI patients: monocentric study in PRAGUE-18 trial participants;Xenobiotica;2020-03-30

4. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing;European Journal of Pharmaceutical Sciences;2019-01

5. Evaluation of Tolerability, Pharmacokinetics and Pharmacodynamics of Vicagrel, a Novel P2Y12 Antagonist, in Healthy Chinese Volunteers;Frontiers in Pharmacology;2018-06-20

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