Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket-Reference-Cited by-同舟云学术

Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket

Published:2016-10-14 Issue:22 Volume:59 Page:10163-10175
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lerner Christian¹,Jakob-Roetne Roland¹,Buettelmann Bernd¹,Ehler Andreas¹,Rudolph Markus¹,Rodríguez Sarmiento Rosa María¹

Affiliation:

1. Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel, Switzerland

Funder

F. Hoffmann-La Roche

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00927

Reference34 articles.

1. Treatment of Cognitive Deficits Associated with Schizophrenia

2. Catechol-O-Methyl Transferase as a Drug Target for Schizophrenia

3. Medicinal Chemistry of Catechol O-Methyltransferase (COMT) Inhibitors and Their Therapeutic Utility