Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability-Reference-Cited by-同舟云学术

Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability

Published:2016-05-26 Issue:11 Volume:59 Page:5284-5296
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pettersson Martin¹,Hou Xinjun¹,Kuhn Max²,Wager Travis T.¹,Kauffman Gregory W.³,Verhoest Patrick R.¹

Affiliation:

1. Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States

2. Research Statistics, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States

3. Computational ADME Group, Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00027

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