Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer’s Disease-Reference-Cited by-同舟云学术

Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer’s Disease

Published:2024-06-07 Issue:12 Volume:67 Page:10248-10262
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pettersson Martin¹^ORCID,Johnson Douglas S.¹^ORCID,Humphrey John M.²,am Ende Christopher W.²^ORCID,Butler Todd W.²,Dorff Peter H.²,Efremov Ivan V.²,Evrard Edelweiss¹,Green Michael E.¹,Helal Christopher J.²^ORCID,Kauffman Gregory W.¹,Mullins Patrick B.²,Navaratnam Thayalan²,O’Donnell Christopher J.²^ORCID,O’Sullivan Theresa J.²,Patel Nandini C.¹^ORCID,Stepan Antonia F.¹,Stiff Cory M.²,Subramanyam Chakrapani²,Trapa Patrick¹,Tran Tuan P.²^ORCID,Vetelino Beth Cooper²,Yang Eddie²,Xie Longfei²,Pustilnik Leslie R.²,Steyn Stefanus J.¹,Wood Kathleen M.²,Bales Kelly R.¹,Hajos-Korcsok Eva¹,Verhoest Patrick R.¹

Affiliation:

1. Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States

2. Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00580

Reference63 articles.

1. Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020–2060)

2. Alzheimer’sAssociation. Alzheimer’s Disease Facts and Figures. https://www.alz.org/media/documents/alzheimers-facts-and-figures.pdf. accessed January 5, 2024.

3. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

4. Presenilins and -Secretase: Structure, Function, and Role in Alzheimer Disease

5. An atomic structure of human γ-secretase