Pentafluorosulfanyl-Substituted Benzopyran Analogues As New Cyclooxygenase-2 Inhibitors with Excellent Pharmacokinetics and Efficacy in Blocking Inflammation-Reference-Cited by-同舟云学术

Pentafluorosulfanyl-Substituted Benzopyran Analogues As New Cyclooxygenase-2 Inhibitors with Excellent Pharmacokinetics and Efficacy in Blocking Inflammation

Published:2017-05-05 Issue:10 Volume:60 Page:4135-4146
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Yanmei¹^ORCID,Wang Yican¹,He Chuang¹,Liu Xiaorong¹,Lu Yongzhi¹,Chen Tingting¹,Pan Qiong¹,Xiong Jingfang¹,She Miaoqin¹,Tu Zhengchao¹,Qin Xiaochu¹,Li Minke¹,Tortorella Micky D.¹,Talley John J.²

Affiliation:

1. Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health, 190 Kaiyuan Avenue, Science City, Guangzhou 510530, P.R. China

2. Euclises Pharmaceuticals, St. Louis, Missouri 63108, United States

Funder

Guangdong Science and Technology Department

Guangzhou Science and Technology Program key projects

Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01484

Reference68 articles.

1. Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties

2. Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery

3. Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules

4. The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine

5. Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine

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