The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

Author:

Benchekroun Mohamed1,Romero Alejandro2,Egea Javier34,León Rafael34,Michalska Patrycja34,Buendía Izaskun34,Jimeno María Luisa5,Jun Daniel6,Janockova Jana7,Sepsova Vendula6,Soukup Ondrej7,Bautista-Aguilera Oscar M.1,Refouvelet Bernard1,Ouari Olivier8,Marco-Contelles José9,Ismaili Lhassane1

Affiliation:

1. Neurosciences Intégratives et Cliniques EA 481, Laboratoire de Chimie Organique et Thérapeutique, UFR SMP, Université Bourgogne Franche-Comté, 19 rue Ambroise Paré, CS 25000 Besançon, France

2. Department of Toxicology & Pharmacology, Faculty of Veterinary Medicine, Complutense University of Madrid, E-28040 Madrid, Spain

3. Instituto de Investigación Sanitaria, Servicio de Farmacología Clínica, Hospital Universitario La Princesa, C/Diego de León 62, E-28006 Madrid, Spain

4. Instituto de I+D del Medicamento Teófilo Hernando (ITH), Facultad de Medicina, Universidad Autónoma de Madrid, C/Arzobispo Morcillo 4, E-28029 Madrid, Spain

5. Centro Química Orgánica “Lora-Tamayo” (CENQUIOR), CSIC, C/Juan de la Cierva 3, E-28006 Madrid, Spain

6. Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, CZ-500 01 Hradec Kralove, Czech Republic

7. Biomedical Research Center, University Hospital Hradec Kralove, CZ-500 05 Hradec Kralove, Czech Republic

8. ICR UMR 7273, Aix Marseille University, CNRS, 13013 Marseille, France

9. Laboratory of Medicinal Chemistry, IQOG, CSIC, C/Juan de la Cierva 3, E-28006 Madrid, Spain

Funder

Bayer

Fundación para la Investigación y la Prevención del Sida en España

Ministerstvo Zdravotnictví Ceské Republiky

Ministerio de Educación, Cultura y Deporte

Instituto de Salud Carlos III

Conseil régional de Franche-Comté

Fakulta vojenského zdravotnictví, Univerzita obrany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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