Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)-Reference-Cited by-同舟云学术

Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)

Published:2017-01-12 Issue:2 Volume:60 Page:627-640
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Castanedo Georgette M.¹^ORCID,Blaquiere Nicole¹,Beresini Maureen¹,Bravo Brandon¹,Brightbill Hans¹,Chen Jacob¹,Cui Hai-Feng²,Eigenbrot Charles¹,Everett Christine¹,Feng Jianwen¹,Godemann Robert³,Gogol Emily¹,Hymowitz Sarah¹,Johnson Adam¹,Kayagaki Nobuhiko¹,Kohli Pawan Bir¹,Knüppel Kathleen³,Kraemer Joachim³,Krüger Susan³,Loke Pui⁴,McEwan Paul⁴,Montalbetti Christian⁴,Roberts David A.¹,Smith Myron⁴,Steinbacher Stefan⁵,Sujatha-Bhaskar Swathi¹,Takahashi Ryan¹,Wang Xiaolu³,Wu Lawren C.¹,Zhang Yamin²,Staben Steven T.¹

Affiliation:

1. Genentech, Inc. 1 DNA Way, South San Francisco, California 94080, United States

2. Pharmaron Beijing Co., Ltd. 6 Taihe Road, BDA, Beijing 100176, P.R. China

3. Manfred Eigen Campus, Evotec AG, Essener Bogen, 22419 Hamburg, Germany

4. Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4Rz, U.K.

5. Proteros Biostructures GmbH, Bunsenstrasse 7a, D-82152 Martinsried, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01363