Design, Synthesis, and Biological Evaluation of a Novel NIK Inhibitor with Anti-Inflammatory and Hepatoprotective Effects for Sepsis Treatment-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of a Novel NIK Inhibitor with Anti-Inflammatory and Hepatoprotective Effects for Sepsis Treatment

Published:2024-04-02 Issue:7 Volume:67 Page:5617-5641
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Nanxia¹^ORCID,Shen Shige²,Yang Mengyu¹,He Sijie¹,Liu Chunxiao²,Li Hongmei¹,Lu Tao¹³,Liu Haichun⁴,Hu Qinghua²^ORCID,Tang Weifang¹^ORCID,Chen Yadong¹³^ORCID

Affiliation:

1. School of Sciences, China Pharmaceutical University, Nanjing 211198, P. R. China

2. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, P. R. China

3. State Key Laboratory of Natural Medicines, School of Science, China Pharmaceutical University, Nanjing 211198, P. R. China

4. Laboratory of Molecular Design and Drug Discovery, School of Sciences, China Pharmaceutical University, Nanjing 211198, P. R. China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02266

Reference60 articles.

1. Sepsis and septic shock

2. Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses

3. Organ dysfunction as a new standard for defining sepsis

4. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

5. Postcritical illness vulnerability

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