Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe-Reference-Cited by-同舟云学术

Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe

Published:2017-01-09 Issue:2 Volume:60 Page:695-709
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Humphreys Philip G.^ORCID,Bamborough Paul,Chung Chun-wa,Craggs Peter D.,Gordon Laurie,Grandi Paola¹,Hayhow Thomas G.,Hussain Jameed,Jones Katherine L.,Lindon Matthew,Michon Anne-Marie¹,Renaux Jessica F.,Suckling Colin J.²,Tough David F.,Prinjha Rab K.

Affiliation:

1. Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, 69117 Heidelberg, Germany

2. WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow, G1 1XL, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01566

Reference73 articles.

1. Small Molecule Bromodomain Inhibitors

2. Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites

3. Suppression of inflammation by a synthetic histone mimic

4. Selective inhibition of BET bromodomains

5. Place your BETs: the therapeutic potential of bromodomains

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