A Rational Design of a Selective Inhibitor for Kv1.1 Channels Prevalent in Demyelinated Nerves That Improves Their Impaired Axonal Conduction-Reference-Cited by-同舟云学术

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A Rational Design of a Selective Inhibitor for Kv1.1 Channels Prevalent in Demyelinated Nerves That Improves Their Impaired Axonal Conduction

Published:2017-03-13 Issue:6 Volume:60 Page:2245-2256
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Al-Sabi Ahmed,Daly Declan,Hoefer Patrick,Kinsella Gemma K.¹,Metais Charles,Pickering Mark²,Herron Caroline³,Kaza Seshu Kumar,Nolan Kieran,Dolly J. Oliver

Affiliation:

1. School of Food Science and Environmental Health, College of Sciences and Health, Dublin Institute of Technology, Cathal Brugha Street, Dublin 1, Ireland

2. UCD School of Medicine, University College Dublin, Dublin, Ireland

3. School of Biomolecular and Biomed Science, Conway Institute, Belfield, Dublin 4, Ireland

Funder

Science Foundation Ireland

Irish Research Council

European Regional Development Fund

Dublin City University

Higher Education Authority

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01262

Reference51 articles.

1. K+ channelepsy: progress in the neurobiology of potassium channels and epilepsy

2. Deletion of the KV1.1 Potassium Channel Causes Epilepsy in Mice

3. Episodic Ataxia Type-1 Mutations in the Kv1.1 Potassium Channel Display Distinct Folding and Intracellular Trafficking Properties

4. Oligomeric properties of .alpha.-dendrotoxin-sensitive potassium ion channels purified from bovine brain

5. Antibodies specific for distinct Kv subunits unveil a heterooligomeric basis for subtypes of .alpha.-dendrotoxin-sensitive potassium channels in bovine brain

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2. Interactions of the Kv1.1 Channel with Peptide Pore Blockers: A Fluorescent Analysis on Mammalian Cells;Membranes;2023-07-04

3. AgTx2-GFP, Fluorescent Blocker Targeting Pharmacologically Important Kv1.x (x = 1, 3, 6) Channels;Toxins;2023-03-18

4. Synthesis of model southern rim structures of photosynthetic tetrapyrroles and phyllobilins;New Journal of Chemistry;2023

5. Quinazolinone dimers as a potential new class of safer Kv1 inhibitors: Overcoming hERG, sodium and calcium channel affinities;Bioorganic Chemistry;2021-10

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