Quinazolinone dimers as a potential new class of safer Kv1 inhibitors: Overcoming hERG, sodium and calcium channel affinities

Author:

Emam Aya M.,Peigneur Steve,Depuydt Anne-Sophie,Ibrahim Samy M.,Lopes Pinheiro-Junior Ernesto,El-Sadek Mohamed,Hendrickx Louise,Tytgat Jan,Kothayer Hend

Funder

Fonds Wetenschappelijk Onderzoek Vlaanderen

KU Leuven

Fundação de Amparo à Pesquisa do Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference65 articles.

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2. Voltage-gated potassium channels as therapeutic targets;Wulff;Nat Rev Drug Discov,2009

3. Pharmacological modulation of voltage-gated potassium channels as a therapeutic strategy;Castle;Expert Opin. Ther. Pat.,2010

4. Potassium channels as therapeutic targets for autoimmune disorders;Wulff;Current opinion in drug discovery & development,2003

5. Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach;Kajanus;Bioorg. Med. Chem. Lett.,2016

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