Neurosteroid-like Inhibitors of N-Methyl-d-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene-Reference-Cited by-同舟云学术

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Neurosteroid-like Inhibitors of N-Methyl-d-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene

Published:2016-04-26 Issue:10 Volume:59 Page:4724-4739
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Slavikova Barbora¹,Chodounska Hana¹,Nekardova Michaela¹²,Vyklicky Vojtech³,Ladislav Marek³,Hubalkova Pavla³,Krausova Barbora³,Vyklicky Ladislav³,Kudova Eva¹

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nam. 2, Dejvice, Prague 6, 16610, Czech Republic

2. Faculty of Mathematics and Physics, Charles University in Prague, Ke Karlovu 3, Prague 2, 121 16, Czech Republic

3. Institute of Physiology CAS, Videnska 1083, 142 20 Prague 4, Czech Republic

Funder

Akademie ved Ceské Republiky

Technologická Agentura Ceské Republiky

Grantová Agentura Ceské Republiky

European Regional Development Fund

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00079

Reference38 articles.

1. Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms

2. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer?s disease

3. Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

4. Excitotoxicity and stroke: Identifying novel targets for neuroprotection

5. Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate

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2. GluN2B subunit selective N-methyl-D-aspartate receptor ligands: Democratizing recent progress to assist the development of novel neurotherapeutics;Molecular Diversity;2023-06-02

3. Effects of Pregnanolone Glutamate and Its Metabolites on GABA_A and NMDA Receptors and Zebrafish Behavior;ACS Chemical Neuroscience;2023-05-01

4. Synthesis, crystal structure and computational studies of new steroidal hemisuccinyl ester derivatives;Journal of Molecular Structure;2023-01

5. Pregnane‐based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss‐of‐function disease‐associated GRIN mutations;British Journal of Pharmacology;2022-04-08

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