Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)-Reference-Cited by-同舟云学术

Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

Published:2016-05-05 Issue:10 Volume:59 Page:4778-4789
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Walji Abbas M.¹,Hostetler Eric D.²,Selnick Harold¹,Zeng Zhizhen²,Miller Patricia²,Bennacef Idriss²,Salinas Cristian²,Connolly Brett²,Gantert Liza²,Holahan Marie²,O’Malley Stacey²,Purcell Mona²,Riffel Kerry²,Li Jing³,Balsells Jaume³,OBrien Julie A.⁴,Melquist Stacey⁴,Soriano Aileen⁵,Zhang Xiaoping⁵,Ogawa Aimie⁵,Xu Serena⁵,Joshi Elizabeth⁶,Della Rocca Joseph⁷,Hess Fred J.⁸,Schachter Joel⁸,Hesk David⁹,Schenk David⁹,Struyk Arie¹⁰,Babaoglu Kerim¹¹,Lohith Talakad G.²,Wang Yaode¹²,Yang Kun¹²,Fu Jianmin¹²,Evelhoch Jeffrey L.²,Coleman Paul J.¹

Affiliation:

1. Discovery Chemistry, Merck & Co., Inc., West Point Pennsylvania 19486, United States

2. Imaging, Merck & Co., Inc., West Point Pennsylvania 19486, United States

3. Process Chemistry, Merck & Co., Inc., West Point Pennsylvania 19486, United States

4. Pharmacology, Merck & Co., Inc., West Point Pennsylvania 19486, United States

5. Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

6. Drug Metabolism, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

7. Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

8. Neuroscience, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

9. Labelled Compound Synthesis, Merck & Co., Inc., Rahway, New Jersey, 07065, United States

10. Clinical Pharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

11. Computational Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

12. Pharmaron Beijing Co., Ltd., Beijing 100176, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00166

Reference51 articles.

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