Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation-Reference-Cited by-同舟云学术

Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation

Published:2016-07-21 Issue:15 Volume:59 Page:7111-7124
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hao Yongjia¹,Wang Xia¹,Zhang Tao²,Sun Deheng¹,Tong Yi¹,Xu Yuqiong¹,Chen Haiyang¹,Tong Linjiang²,Zhu Lili¹,Zhao Zhenjiang¹,Chen Zhuo¹,Ding Jian²,Xie Hua²,Xu Yufang¹,Li Honglin¹

Affiliation:

1. Shanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China

2. Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

Funder

Ministry of Education of the People's Republic of China

Ministry of Science and Technology of the People's Republic of China

Fok Ying Tong Education Foundation

Shanghai Municipal Education Commission

National Natural Science Foundation of China

Shanghai Committee of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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