Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-d]pyrimidine Scaffold-Reference-Cited by-同舟云学术

Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-d]pyrimidine Scaffold

Published:2011-11-04 Issue:23 Volume:54 Page:8030-8050
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ishikawa Tomoyasu¹,Seto Masaki¹,Banno Hiroshi¹,Kawakita Youichi¹,Oorui Mami¹,Taniguchi Takahiko¹,Ohta Yoshikazu¹,Tamura Toshiya¹,Nakayama Akiko¹,Miki Hiroshi¹,Kamiguchi Hidenori¹,Tanaka Toshimasa¹,Habuka Noriyuki¹,Sogabe Satoshi¹,Yano Jason²,Aertgeerts Kathleen²,Kamiyama Keiji¹

Affiliation:

1. Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

2. Structural Biology, Takeda San Diego, Inc., 10410 Science Center Drive, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2008634

Reference55 articles.

1. The erbB gene of avian erythroblastosis virus is a member of the src gene family

2. Tyrosine kinases as targets in cancer therapy – successes and failures