Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor

Author:

Michino Mayako1,Boateng Comfort A.23,Donthamsetti Prashant4,Yano Hideaki1,Bakare Oluyomi M.2,Bonifazi Alessandro2,Ellenberger Michael P.2,Keck Thomas M.25ORCID,Kumar Vivek2,Zhu Clare1,Verma Ravi1,Deschamps Jeffrey R.6,Javitch Jonathan A.4,Newman Amy Hauck2ORCID,Shi Lei1ORCID

Affiliation:

1. Computational Chemistry and Molecular Biophysics Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse—Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States

2. Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse—Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States

3. Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States

4. Departments of Psychiatry and Pharmacology, Columbia University College of Physicians and Surgeons, and Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, United States

5. Department of Chemistry and Biochemistry, and Department of Biomedical and Translational Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States

6. Naval Research Laboratory, Code 6930, 4555 Overlook Avenue, Washington, DC 20375, United States

Funder

National Institute on Drug Abuse

National Institute of Mental Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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