Design and Synthesis of trans-N-[4-[2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2- yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A Potent and Selective Dopamine D3 Receptor Antagonist with High Oral Bioavailability and CNS Penetration in the Rat-Reference-Cited by-同舟云学术

Design and Synthesis of trans-N-[4-[2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2- yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A Potent and Selective Dopamine D3 Receptor Antagonist with High Oral Bioavailability and CNS Penetration in the Rat

Published:2000-04-18 Issue:9 Volume:43 Page:1878-1885
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Stemp Geoffrey¹,Ashmeade Tracey¹,Branch Clive L.¹,Hadley Michael S.¹,Hunter A. Jacqueline¹,Johnson Christopher N.¹,Nash David J.¹,Thewlis Kevin M.¹,Vong Antonio K. K.¹,Austin Nigel E.¹,Jeffrey Phillip¹,Avenell Kim Y.¹,Boyfield Izzy¹,Hagan Jim J.¹,Middlemiss Derek N.¹,Reavill Charlie¹,Riley Graham J.¹,Routledge Carole¹,Wood Martyn¹

Affiliation:

1. Departments of Discovery Chemistry, Neuroscience Research, and Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000090i

Reference23 articles.

1. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

2. The D 3 dopamine receptor in cellular and organismal function

3. Linking the Family of D2 Receptors to Neuronal Circuits in Human Brain: Insights into Schizophrenia

4. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

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