Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux-Reference-Cited by-同舟云学术

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Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux

Published:2016-08-30 Issue:18 Volume:59 Page:8441-8455
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gorityala Bala Kishan¹,Guchhait Goutam¹,Goswami Sudeep¹,Fernando Dinesh M.²,Kumar Ayush²³,Zhanel George G.³,Schweizer Frank¹³

Affiliation:

1. Department of Chemistry, University of Manitoba, 144 Dysart Road, 450 Parker Building, Winnipeg, Manitoba R3T 2N2, Canada

2. Department of Microbiology, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada

3. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3T 1R9, Canada

Funder

Canadian Institutes of Health Research

Institute of Infection and Immunity

Natural Sciences and Engineering Research Council of Canada

Manitoba Health Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00867

Reference49 articles.

1. Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

2. Hospital-Acquired Infections Due to Gram-Negative Bacteria

3. Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study

4. Overview of Nosocomial Infections Caused by Gram-Negative Bacilli

5. Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Annual Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007

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2. Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens;npj Antimicrobials and Resistance;2023-12-20

3. Photoswitchable Antibiotic Hybrids: Spacer Length-Dependent Photochemical Control of Antibacterial Activity;Bioconjugate Chemistry;2023-12-19

4. Multitarget antibacterial drugs: An effective strategy to combat bacterial resistance;Pharmacology & Therapeutics;2023-12

5. Guanidinylated Amphiphilic Tobramycin Derivatives Synergize with β-Lactam/β-Lactamase Inhibitor Combinations against Pseudomonas aeruginosa;ACS Infectious Diseases;2023-08-21

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