Enhancing outer membrane permeability of tetracycline antibiotics in <i>P. aeruginosa</i> using TOB

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Enhancing outer membrane permeability of tetracycline antibiotics in P. aeruginosa using TOB–CIP conjugates

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Dhiman Shiv¹,Ramirez Danyel¹,Arora Rajat¹^ORCID,Arthur Gilbert²,Schweizer Frank¹³^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada

2. Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada

3. Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada

Abstract

Pseudomonas aeruginosa is an opportunistic critical ‘priority 1’ Gram-negative bacterium that poses a severe threat to public healthcare due to rising antibiotic resistance.

Funder

Institute of Infection and Immunity

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00329B

Reference55 articles.

1. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

2. Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist1*Address for correspondence: Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA

3. Permeability barriers of Gram‐negative pathogens

4. Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?

5. Outer membrane permeability and antibiotic resistance

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