A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway

Author:

Xu Shengtao1,Yao Hong1,Luo Shanshan2,Zhang Yun-Kai3,Yang Dong-Hua3,Li Dahong14,Wang Guangyu1,Hu Mei1,Qiu Yangyi1,Wu Xiaoming1,Yao Hequan1ORCID,Xie Weijia1,Chen Zhe-Sheng3,Xu Jinyi1ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China

2. Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, P. R. China

3. College of Pharmacy and Health Sciences, St. John’s University, 8000 Utopia Parkway, Queens, New York 11439, United States

4. Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wen Hua Road, Shenyang 110016, China

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

State Key Laboratory of Natural Medicines, China Pharmaceutical University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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