Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts

Author:

Patil Satish1,Lis Lev G.1,Schumacher Robert J.2,Norris Beverly J.2,Morgan Monique L.2,Cuellar Rebecca A. D.1,Blazar Bruce R.2,Suryanarayanan Raj3,Gurvich Vadim J.1,Georg Gunda I.1

Affiliation:

1. Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, United States

2. Center for Translational Medicine, Academic Health Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, Minnesota 55455, United States

3. Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States

Funder

College of Pharmacy, University of Minnesota

National Cancer Institute

Board of Regents, University of Minnesota

Center for Translational Medicine, University of Minnesota

William and Mildred Peters Endowment Fund

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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