Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors-Reference-Cited by-同舟云学术

Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors

Published:2016-07-07 Issue:15 Volume:59 Page:7212-7222
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Elgaher Walid A. M.¹,Sharma Kamal K.²,Haupenthal Jörg¹,Saladini Francesco³,Pires Manuel²,Real Eleonore²,Mély Yves²,Hartmann Rolf W.¹

Affiliation:

1. Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS); and Pharmaceutical and Medicinal Chemistry, Saarland University, Campus E8.1, 66123 Saarbrücken, Germany

2. Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie, UMR 7213 CNRS, Université de Strasbourg, 74 Route du Rhin, 67401 Illkirch, France

3. Department of Medical Biotechnologies, University of Siena, Viale Mario Bracci 16, 53100 Siena, Italy

Funder

Deutscher Akademischer Austauschdienst

European Commission

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00730

Reference41 articles.

1. WHO. HIV/AIDS, Fact Sheet No. 360, 2015.http://www.who.int/mediacentre/factsheets/fs360/en/.