Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa–Tissue Factor Complex-Reference-Cited by-同舟云学术

Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa–Tissue Factor Complex

Published:2016-08-02 Issue:15 Volume:59 Page:7125-7137
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Xiaojun¹,Glunz Peter W.¹,Johnson James A.¹,Jiang Wen¹,Jacutin-Porte Swanee¹,Ladziata Vladimir¹,Zou Yan¹,Phillips Monique S.¹,Wurtz Nicholas R.¹,Parkhurst Brandon¹,Rendina Alan R.²,Harper Timothy M.²,Cheney Daniel L.¹,Luettgen Joseph M.²,Wong Pancras C.²,Seiffert Dietmar²,Wexler Ruth R.¹,Priestley E. Scott¹

Affiliation:

1. Bristol-Myers Squibb R&D, 350 Carter Road, Hopewell, New Jersey 08540, United States

2. Bristol-Myers Squibb R&D, 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00469

Reference36 articles.

1. Recent Research Developments in the Direct Inhibition of Coagulation Proteinases – Inhibitors of the Initiation Phase

2. Factor VIIa Modified in the 170 Loop Shows Enhanced Catalytic Activity but Does Not Change the Zymogen-like Property