Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles

Published:2016-08-26 Issue:17 Volume:59 Page:7991-8007
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kang Dongwei¹,Fang Zengjun¹²,Li Zhenyu¹,Huang Boshi¹,Zhang Heng¹,Lu Xueyi¹,Xu Haoran¹,Zhou Zhongxia¹,Ding Xiao¹,Daelemans Dirk³,De Clercq Erik³,Pannecouque Christophe³,Zhan Peng¹,Liu Xinyong¹

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan 250012, Shandong P.R. China

2. The Second Hospital, Shandong University, No. 247 Beiyuan Avenue, Jinan 250033, China

3. Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

Funder

Ministry of Education of the People's Republic of China

Shandong Province

National Natural Science Foundation of China

Bijzonder Onderzoeksfonds

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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