Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability-Reference-Cited by-同舟云学术

Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability

Published:2016-12-13 Issue:24 Volume:59 Page:11027-11038
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Crowley Rachel Saylor¹,Riley Andrew P.²,Sherwood Alexander M.¹,Groer Chad E.¹,Shivaperumal Nirajmohan³,Biscaia Miguel³,Paton Kelly³,Schneider Sebastian⁴,Provasi Davide⁴,Kivell Bronwyn M.³,Filizola Marta⁴^ORCID,Prisinzano Thomas E.¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, The University of Kansas, 1251 Wescoe Hall Drive, 4070 Malott, Lawrence, Kansas 66045, United States

2. Department of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States

3. Centre for Biodiscovery, School of Biological Sciences, Victoria University of Wellington, Wellington 6140, New Zealand

4. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

Funder

Neurological Foundation of New Zealand

Health Research Council of New Zealand

Victoria University of Wellington

National Institute on Drug Abuse

National Institute on Minority Health and Health Disparities

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01235

Reference43 articles.

1. aInstitute of Medicine (U.S.). Committee on Advancing Pain Research Care and Education. Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research;National Academies Press:Washington, DC, 2011; pxvii.

2. Opioids, sensory systems and chronic pain

3. Increases in Drug and Opioid Overdose Deaths — United States, 2000–2014

4. aWilliams, D. A.; Roche, V. F.; Roche, E. B.Foye’s Principles of Medicinal Chemistry,7thed.Wolters Kluwer Health/Lippincott Williams & Wilkins:Philadelphia, 2013; p658–699;

Cited by 37 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression;Journal of Medicinal Chemistry;2024-05-29

2. From Plant to Chemistry: Sources of Active Opioid Antinociceptive Principles for Medicinal Chemistry and Drug Design;Molecules;2023-10-14

3. Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans;Molecules;2023-06-15

4. Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor;Journal of Medicinal Chemistry;2023-02-24

5. Solving an Old Puzzle: Elucidation and Evaluation of the Binding Mode of Salvinorin A at the Kappa Opioid Receptor;Molecules;2023-01-11