Synthesis and Evaluation of Novel Radioligands Based on 3-[5-(Pyridin-2-yl)-2H-tetrazol-2-yl]benzonitrile for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor Subtype 5-Reference-Cited by-同舟云学术

Synthesis and Evaluation of Novel Radioligands Based on 3-[5-(Pyridin-2-yl)-2H-tetrazol-2-yl]benzonitrile for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor Subtype 5

Published:2016-04-13 Issue:8 Volume:59 Page:3980-3990
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shimoda Yoko¹,Yamasaki Tomoteru¹,Fujinaga Masayuki¹,Ogawa Masanao¹²,Kurihara Yusuke¹²,Nengaki Nobuki¹²,Kumata Katsushi¹,Yui Joji¹,Hatori Akiko¹,Xie Lin¹,Zhang Yiding¹,Kawamura Kazunori¹,Zhang Ming-Rong¹

Affiliation:

1. Department of Radiopharmaceuticals Development, Radiological Science Research and Development Directorate, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan

2. SHI Accelerator Service Co. Ltd., 1-17-6 Osaki, Shinagawa-ku, Tokyo 141-0032, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00209

Reference43 articles.

1. Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives

2. Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors

3. Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells

4. Role of the Second and Third Intracellular Loops of Metabotropic Glutamate Receptors in Mediating Dual Signal Transduction Activation

5. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.

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