Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome

Author:

Zhang Hao1ORCID,Hsu Hao-Chi2,Kahne Shoshanna C.3,Hara Ryoma4,Zhan Wenhu1ORCID,Jiang Xiuju1,Burns-Huang Kristin1,Ouellette Tierra1,Imaeda Toshihiro4,Okamoto Rei4,Kawasaki Masanori4,Michino Mayako4,Wong Tzu-Tshin4,Toita Akinori4,Yukawa Takafumi4,Moraca Francesca5ORCID,Vendome Jeremie5,Saha Priya1,Sato Kenjiro4,Aso Kazuyoshi4,Ginn John4,Meinke Peter T.4,Foley Michael4,Nathan Carl F.1,Darwin K. Heran3,Li Huilin2ORCID,Lin Gang1ORCID

Affiliation:

1. Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Avenue, New York, New York 10065, United States

2. Department of Structural Biology, Van Andel Institute, 333 Bostwick Avenue NE, Grand Rapids, Michigan 49503, United States

3. Department of Microbiology, New York University School of Medicine, 430 E. 29th Street, New York, New York 10016, United States

4. Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th Street, New York, New York 10065, United States

5. Schrödinger, Inc., New York, New York 10036, United States

Funder

Takeda Pharmaceutical Company

National Institute of Allergy and Infectious Diseases

Michigan Economic Development Corporation

National Institutes of Health

Milstein Program in Translational Medicine

Tri-Institutional Therapeutics Discovery Institute

Weill Cornell Medicine Matching Fund

Michigan Technology Tri-Corridor

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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