Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure–Activity Relationship, and Molecular Modeling Studies-Reference-Cited by-同舟云学术

Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure–Activity Relationship, and Molecular Modeling Studies

Published:2021-12-02 Issue:24 Volume:64 Page:17866-17886
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Guan Dongliang¹^ORCID,Rahman Md Toufiqur¹^ORCID,Gay Elaine A.¹,Vasukuttan Vineetha¹,Mathews Kelly M.¹,Decker Ann M.¹^ORCID,Williams Alexander H.²,Zhan Chang-Guo²,Jin Chunyang¹^ORCID

Affiliation:

1. Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States

2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States

Funder

Division of Chemistry

National Center for Advancing Translational Sciences

National Institute on Alcohol Abuse and Alcoholism

National Institute on Drug Abuse

National Institute of General Medical Sciences

College of Pharmacy, University of Kentucky

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01081

Reference50 articles.

1. Distribution, physiology and pharmacology of relaxin‐3/RXFP3 systems in brain

2. Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin‐3/RXFP3 system in neuropsychiatric disorders

3. Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat

4. Distribution of G-Protein-Coupled Receptor (GPCR)135 Binding Sites and Receptor mRNA in the Rat Brain Suggests a Role for Relaxin-3 in Neuroendocrine and Sensory Processing

5. Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation

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