Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure–Activity Relationship, and Molecular Modeling Studies
Author:
Affiliation:
1. Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States
2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States
Funder
Division of Chemistry
National Center for Advancing Translational Sciences
National Institute on Alcohol Abuse and Alcoholism
National Institute on Drug Abuse
National Institute of General Medical Sciences
College of Pharmacy, University of Kentucky
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01081
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2. Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin‐3/RXFP3 system in neuropsychiatric disorders
3. Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat
4. Distribution of G-Protein-Coupled Receptor (GPCR)135 Binding Sites and Receptor mRNA in the Rat Brain Suggests a Role for Relaxin-3 in Neuroendocrine and Sensory Processing
5. Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation
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