Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8<i>H</i>)-one Derivatives as Novel Potent Adenosine A<sub>2A</sub> Receptor Antagonists for Cancer Immunotherapy-Reference-Cited by-同舟云学术

Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8H)-one Derivatives as Novel Potent Adenosine A_2A Receptor Antagonists for Cancer Immunotherapy

Published:2022-02-25 Issue:5 Volume:65 Page:4367-4386
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yu Fazhi¹,Zhu Chenyu¹,Ze Shuyin²,Wang Haojie¹,Yang Xinyu²,Liu Mingyao²^ORCID,Xie Qiong¹³,Lu Weiqiang²^ORCID,Wang Yonghui¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China

2. Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China

3. Fudan Zhangjiang Institute, 666 Zhangheng Road, Shanghai 201203, China

Funder

Natural Science Foundation of Shanghai

National Natural Science Foundation of China

National Science and Technology Major Project

National Key Scientific Infrastructure for Translational Medicine (Shanghai)

Shanghai Biopharmaceutical and Technology Supporting Plan

Shanghai Committee of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine