Subtle Structural Changes across the Boundary between A2AR/A2BR Dual Antagonism and A2BR Antagonism: A Novel Class of 2-Aminopyrimidine-Based Derivatives-Reference-Cited by-同舟云学术

Subtle Structural Changes across the Boundary between A_2AR/A_2BR Dual Antagonism and A_2BR Antagonism: A Novel Class of 2-Aminopyrimidine-Based Derivatives

Published:2024-03-14 Issue:6 Volume:67 Page:5075-5092
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Haojie¹,Yang Xinyu²,Li Yan¹^ORCID,Ze Shuyin³,Feng Bo⁴,Weng Yuan³,Gao Aoqi³,Song Gaojie³,Liu Mingyao³⁵^ORCID,Xie Qiong¹^ORCID,Wang Yonghui¹^ORCID,Lu Weiqiang²^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China

2. Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, Shanghai Key Laboratory of Multidimensional Information Processing, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China

3. Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China

4. Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

5. Shanghai Yuyao Biotech Co., Ltd., Shanghai 200041, China

Funder

East China Normal University

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00250

Reference47 articles.

1. Inhibition of the Adenosine Pathway to Potentiate Cancer Immunotherapy: Potential for Combinatorial Approaches

2. Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

3. Pharmacology of Adenosine Receptors: The State of the Art

4. Role of adenosine A2a receptor in cancers and autoimmune diseases

5. Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases

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