Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors

Author:

Henderson Scott H.1ORCID,Sorrell Fiona2,Bennett James3,Fedorov Oleg3,Hanley Marcus T.4,Godoi Paulo H.5,Ruela de Sousa Roberta5,Robinson Sean6ORCID,Ashall-Kelly Alexander4,Hopkins Navratilova Iva67,Walter Daryl S.8,Elkins Jonathan M.25ORCID,Ward Simon E.4ORCID

Affiliation:

1. Sussex Drug Discovery Centre, University of Sussex, Brighton BN1 9RH, U.K.

2. Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, U.K.

3. Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, U.K.

4. Medicines Discovery Institute, Cardiff University, Cardiff CF10 3AT, U.K.

5. Structural Genomics Consortium, Universidade Estadual de Campinas, Cidade Universitária Zeferino Vaz, Av. Dr. André Tosello, 550, Barão Geraldo, Campinas, SP 13083-886, Brazil

6. Exscientia, The Schrödinger Building, Oxford Science Park, Oxford OX4 4GE, U.K.

7. University of Dundee, Dow Street, Dundee DD1 5EH, U.K

8. Evotec (UK) Ltd., 112-114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.

Funder

Merck Sharp and Dohme

Novartis Farmac??utica

Takeda Pharmaceuticals U.S.A.

Bayer

Merck KGaA

Pfizer

Cancer Research Wales

Ontario Ministry of Economic Development and Innovation

Innovative Medicines Initiative

Genome Canada

Wellcome Trust

AbbVie

Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo

Boehringer Ingelheim

Janssen Pharmaceuticals

Eshelman Institute for Innovation, University of North Carolina

Medical Research Council

Canada Foundation for Innovation

Biotechnology and Biological Sciences Research Council

European Structural Funding

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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