Supercoiling Structure-Based Design of a Trimeric Coiled-Coil Peptide with High Potency against HIV-1 and Human β-Coronavirus Infection

Author:

Wang Chao1,Xia Shuai2,Wang Xinling2,Li Yue1,Wang Huan1,Xiang Rong3,Jiang Qinwen4,Lan Qiaoshuai2,Liang Ruiying3,Li Qing1,Huo Shanshan3,Lu Lu2,Wang Qian2,Yu Fei3,Liu Keliang1ORCID,Jiang Shibo25ORCID

Affiliation:

1. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 27 Tai-Ping Road, Beijing 100850, China

2. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences & Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Road, Shanghai 200032, China

3. Hebei Center for Wildlife Health, College of Life Sciences, Hebei Agricultural University, Baoding 071001, China

4. Key Laboratory of Structure-based Drug Design & Discovery of the Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China

5. Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York 10065, United States

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Department of S and T for Social Development

Program for ?333 Talents Project? of Hebei Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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